Particles in lipid bilayers

Scaling Cascades in Complex Systems
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Model of clathrin-mediated endocytosis
Model of clathrin-mediated endocytosis
Image Credit: Frauke Ackermann, Joshua A. Gregory and Lennart Brodin
Amphiphysin trapped coated pits with narrow necks
Amphiphysin trapped coated pits with narrow necks
Image Credit: Frauke Ackermann, Joshua A. Gregory and Lennart Brodin

Staff:

Prof. Dr. Carsten Gräser, Prof. Dr. Carsten Hartmann, Prof. Dr. Ralf Kornhuber, Tobias Kies, Maren-Wanda Wolf

Financial support:

Freie Universität Berlin

Term:

Oct 01, 2014 — Sep 30, 2018

Homepage:

The interplay of proteins and curvature of lipid bilayers is well-known to regulate cell morphology and a variety of cellular functions, such as trafficking or signal detection. Here, interplay not only means that proteins can induce curvature by shaping and re­modeling the membrane, but also that the membrane curvature plays an active role in creating functional membrane domains and organizing membrane proteins, includ­ing their conformation dynamics. Moreover, microscopic causes, such as hydrophobic mismatch of proteins and amphiphilic lipids, may have macroscopic effects, such as budding or fission. For example, the membrane remodeling during endocytosis is a con­sequence of the interplay between the elastic membrane and concerted actions of highly specialized membrane proteins that can both sense and create membrane curvature. In case of the clathrin-mediated endocytosis more than 40 different proteins are involved, many of which are only transiently recruited to the plasma membrane. In this project, we start with mathematically consistent formulations of existing and advanced models and the numerical analysis of related discretization methods and then proceed to suitable upscaling techniques.

Conference:

Geometric partial differential equations: Surface and bulk processes, Oberwolfach Workshop 1549, 29 Nov - 5 Dec 2015,
Organizers: K. Deckelnick, C.M. Elliott, R. Kornhuber, J. Sethian (Proceedings: Oberwolfach Report No. 55/2015)

Publications:

Elliott, C.M. and Gräser, C. and Hobbs, G. and Kornhuber, R. and Wolf, M.W. (2016) A Variational Approach to Particles in Lipid Membranes. Archive for Rational Mechanics and Analysis, 222 (2). pp. 1011-1075. ISSN Print: 0003-9527; Online:1432-0673

Talks:

09/15/2014: R. Kornhuber, A variational approach to particles in bilipid layers, Conference on Interdisciplinary Approaches to Biomembranes, FU Berlin

12/29/2014: A. Djurdjevac, Parabolic partial differential equations on moving spaces, Mathematical seminar, Mathematical Institute, Serbian Academy of Sciences and Arts, Belgrade, Serbia

11/04/2015: R. Kornhuber, Numerical approximation of interacting  particles in lipid membranes, Multi-physics geometric PDEs using deformable surfaces: Analysis, modelling, numerics and applications, University of Sussex, Sussex

11/12/2015 and 12/03/2015: A. Djurdjevac, Monte Carlo evolving surface finite element methods for PDEs with random coefficients on moving hypersurfaces, Workshop "Direct and Inverse Problems for PDEs with Random Coefficients", Weierstrass Institute, Berlin, and Oberwolfach Workshop 1549 "Geometric partial differential equations: Surface and bulk processes", Oberwolfach

12/24/2015: A. Djurdjevac, Parabolic partial differential equations on moving hypersurfaces with random coefficients, Mathematical seminar, Mathematical Institute, Serbian Academy of Sciences and Arts, Belgrade, Serbia

02/18/2016: A. Djurdjevac, Partial differential equations with random coefficients on moving hypersurfaces, 4th BMS Student Conference, Berlin

02/29/2016: R. Kornhuber, Particles and membranes, Efficient Methods for Multiscale Simulations and Data Analysis,
Söll, Austria