The contexts in which sensitive decisions are taking place continuously shift into the digital realm. From a human-computer interaction perspective, critical attention ought to be paid to the design of the user interfaces mediating these decisions, as they have been found to shape them.In my doctoral research project I therefore seek to examine the design space of digital decision-making within a health-care context, aiming to develop approaches for user-interface design that fosters informed decisions in patients. Methodologically, this is approached through combining quantitative (i.e. experiments to evaluate interface design elements) and qualitative (i.e. participatory workshops, value-sensitive design approaches and user evaluations) methods to, first, derive design requirements and, second, develop specific interface design and interaction concepts for selected application cases, situated within a German health-care context.