Proteomics is a relatively young discipline dealing with the complicated protein mixture in each part of the human or animal body. Opposed to e.g. genomics, the players in this area of molecular biology and biochemistry are single molecules like proteins. Their concentration in body fluids (such as blood, urine or eye and brain fluid) often span many orders of magnitude during a day, depending on the varying conditions the human body is exposed to.
During the last years, several new emerging proteomic methods show promise in non-invasive screening of the body fluids mentioned above. The characterization of peptides and proteins in serum and plasma by mass spectrometry (MS) is one of the promising strategies for biomarker discovery. The computer-assisted detection of molecules provides a snapshot of thousands of peptides, protein fragments and proteins. This new analytical technology has the potential to identify disease-associated proteomic patterns in blood serum.